Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
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DOI: 10.1021/acsmedchemlett.9b00666
Abstract: An agonist–antagonist switching strategy was performed to discover novel PPARα antagonists. Phenyldiazenyl derivatives of fibrates were developed, bearing sulfonimide or amide functional groups. A second series of compounds was synthesized, replacing the phenyldiazenyl moiety with… read more here.
Keywords: amide derivatives; novel ppar; ppar antagonists; sulfonimide amide ... See more keywords