α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
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DOI: 10.1021/acs.jmedchem.9b00993
Abstract: The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53–MDM2 PPIs. The… read more here.
Keywords: protein; protein interactions; protein protein; sulfono aapeptides ... See more keywords