Accelerating sulfonyl fluoride synthesis through electrochemical oxidative coupling of thiols and potassium fluoride in flow
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DOI: 10.1007/s41981-019-00070-9
Abstract: Sulfonyl fluorides are valuable synthetic motifs which are currently of high interest due to the popularity of the sulfur (VI) fluoride exchange (SuFEx) click chemistry concept. Herein, we describe a flow chemistry approach to enable… read more here.
Keywords: chemistry; synthesis electrochemical; electrochemical oxidative; sulfonyl fluoride ... See more keywords
Enantioselective Addition of Azlactones to Ethylene Sulfonyl Fluoride via Dual Catalysis.
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DOI: 10.1021/acs.orglett.1c01193
Abstract: Enantioselective conjugate addition of azlactones to ethylene sulfonyl fluoride has been achieved via the cooperative catalysis with (DHQD)2PHAL and a hydrogen-bond donor (HBD). This approach furnishes a facile access to a range of structurally diverse… read more here.
Keywords: addition azlactones; catalysis; sulfonyl fluoride; ethylene sulfonyl ... See more keywords
A General Procedure for the Construction of 2-Alkyl-Substituted Vinyl Sulfonyl Fluoride.
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DOI: 10.1021/acs.orglett.2c03936
Abstract: A series of compact and multifunctional 2-alkyl-substituted vinyl sulfonyl fluorides were efficiently prepared from the corresponding alkyl iodides and 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF). This Giese-type radical approach provided new and general access to alkenyl sulfonyl fluorides,… read more here.
Keywords: vinyl sulfonyl; substituted vinyl; sulfonyl fluoride; sulfonyl ... See more keywords
Molecular design principles of ionic liquids with a sulfonyl fluoride moiety
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DOI: 10.1039/d0nj05603k
Abstract: The continued success of ionic liquids in applications ranging from energy to medicine poses the challenge to rapidly find new functional ionic liquids with desirable properties while developing practical, scalable syntheses. As a SuFExable functionality,… read more here.
Keywords: molecular design; design principles; chemistry; ionic liquids ... See more keywords
Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
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DOI: 10.1039/d3dt00458a
Abstract: Peptidases are regulated by latency and inhibitors, as well as compatibilization and cofactors. Ulilysin from Methanosarcina acetivorans, also called lysargiNase, is an archaeal metallopeptidase (MP) that is biosynthesized as a zymogen with a 60-residue N-terminal… read more here.
Keywords: lysarginase; metallopeptidase; inhibitor; sulfonyl fluoride ... See more keywords