Recent progress in the synthesis of sulfonyl fluorides for SuFEx click chemistry
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.03.035
Abstract: Abstract Since the sulfur(VI) fluoride exchange reaction (SuFEx) was introduced by Sharpless and co-workers in 2014, this new-generation click chemistry has emerged as an efficient and reliable tool for creating modular intermolecular connections. Sulfonyl fluorides,… read more here.
Keywords: synthesis; sulfonyl fluorides; click chemistry; chemistry ... See more keywords
An Investigation into the In Vitro Metabolic Stability of Aryl Sulfonyl Fluorides for their Application in Medicinal Chemistry and Radiochemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00806
Abstract: Molecules that feature a sulfonyl fluoride (SO2F) moiety have been gaining increasing interest due to their unique reactivity and potential applications in synthetic chemistry, medicinal chemistry, and other biological uses. A particular interest is towards… read more here.
Keywords: radiochemistry; stability; chemistry; aryl sulfonyl ... See more keywords
Redox-Neutral Organometallic Elementary Steps at Bismuth: Catalytic Synthesis of Aryl Sulfonyl Fluorides
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11463
Abstract: A Bi-catalyzed synthesis of sulfonyl fluorides from the corresponding (hetero)aryl boronic acids is presented. We demonstrate that the organobismuth(III) catalysts bearing a bis-aryl sulfone ligand backbone revolve through different canonical organometallic steps within the catalytic… read more here.
Keywords: redox neutral; aryl; neutral organometallic; synthesis ... See more keywords
EnT-Mediated N-S Bond Homolysis of a Bifunctional Reagent Leading to Aliphatic Sulfonyl Fluorides.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11295
Abstract: Sulfur(VI) fluoride exchange (SuFEx) gives rise to a plethora of high-valent sulfur linkages; however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the limited sources of introducing the SO2F moiety via a… read more here.
Keywords: reagent; bond homolysis; aliphatic sulfonyl; sulfonyl fluorides ... See more keywords
A rapid access to aliphatic sulfonyl fluorides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11805-6
Abstract: The past few years have witnessed a fast-growing research interest on the study of sulfonyl fluorides as reactive probes in chemical biology and molecular pharmacology, which raises an urgent need for the development of effective… read more here.
Keywords: aliphatic sulfonyl; sulfonyl fluorides; pharmacology; biology ... See more keywords
A diversity oriented clicking strategy: the stereoselective synthesis of highly-functionalised olefins from 2-substituted-alkynyl-1-sulfonyl fluorides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04473k
Abstract: A novel series of addition reactions of highly reactive 2-substituted-alkynyl-1-sulfonyl fluoride (SASF) hubs with DMSO and DMF for the synthesis of two unique sulfonyl fluoride cores is described. The stereoselective chemistry allowed the unprecedented syntheses… read more here.
Keywords: alkynyl sulfonyl; substituted alkynyl; synthesis; diversity oriented ... See more keywords
Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonyl Fluorides
Sign Up to like & getrecommendations! Published in 2023 at "Synthesis"
DOI: 10.1055/a-2067-7071
Abstract: A Pd-catalyzed asymmetric phosphination of α, β-unsaturated sulfonyl fluorides was developed, and a series of tertiary phosphorus compounds were obtained in excellent yields and enantioselectivities (up to 99% ee). The chiral adduct can be further… read more here.
Keywords: unsaturated sulfonyl; palladium catalyzed; asymmetric addition; catalyzed asymmetric ... See more keywords