Mn(OAc)3-Mediated Unexpected Cycloannulative Sulfonyl Migration Cascade using (E)-β-Iodovinyl Sulfones and ortho-Alkynylphenols for Direct Synthesis of Chromene-Derived Vinyl Sulfones.
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DOI: 10.1021/acs.orglett.3c00309
Abstract: Cycloannulative sulfonyl migration has received much attention; however, a carbon-to-carbon sulfonyl group shift still needs to be discovered. We hereby report a base-mediated oxa-Michael addition-elimination of (E)-β-iodovinyl sulfones with ortho-alkynylphenols, followed by cycloisomerization and unique… read more here.
Keywords: iodovinyl sulfones; sulfonyl migration; cycloannulative sulfonyl; sulfones ortho ... See more keywords
De Novo Construction of Chiral Aminoindolines by Cu-Catalyzed Asymmetric Cyclization and Subsequent Discovery of an Unexpected Sulfonyl Migration.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08090
Abstract: Searching for efficient strategies to access structurally novel aminoindolines is of great significance for drug discovery. However, catalytic asymmetric de novo construction of aminoindoline scaffolds with functionality primed for diversification still remains elusive. Here, we… read more here.
Keywords: chiral aminoindolines; sulfonyl migration; catalyzed asymmetric; novo construction ... See more keywords