Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.
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DOI: 10.1021/acsmedchemlett.6b00489
Abstract: A series of 2-sulfonyl-pyrimidinyl derivatives was developed as apoptosis inhibitors. These represent the first class of apoptosis inhibitors that function through stabilizing mitochondrial respiratory complex II. Starting from a phenotypic screen hit with micromolar activity,… read more here.
Keywords: sulfonyl pyrimidinyl; pyrimidinyl derivatives; apoptosis inhibition;