New N-9- sulfonylpurine derivatives induce changes in mitochondrial function and ROS accumulation in carcinoma and leukemia cells in vitro
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DOI: 10.1016/j.freeradbiomed.2018.05.041
Abstract: Our recent studies showed significant antiproliferative capacity of newly synthesized N-9-sulfonylpyrimidine derivatives on human carcinoma, lymphoma, and leukemia cells. These derivatives behave as antimetabolites exploiting cellular metabolism to induce cytotoxicity in treated tumors’ cells [1-3].… read more here.
Keywords: sulfonylpurine; leukemia cells; ros accumulation; changes mitochondrial ... See more keywords