HDAC5–LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells
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DOI: 10.1002/ijc.31419
Abstract: Our recent studies have shown that cross‐talk between histone deacetylase 5 (HDAC5) and lysine‐specific demethylase 1 (LSD1) facilitates breast cancer progression. In this work, we demonstrated that regulatory activity at −356 to −100 bp promoter… read more here.
Keywords: sulforaphane; lsd1; hdac5 lsd1; breast cancer ... See more keywords
Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28609
Abstract: The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a major public health threat worldwide and emphasizes an urgent need for effective therapeutics. Recently, Ordonez… read more here.
Keywords: sulforaphane; inhibitor; like protease; chymotrypsin like ... See more keywords
Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
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DOI: 10.1007/s12272-020-01225-2
Abstract: Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against multiple cancer types including pancreatic, prostate, breast, lung, cervical, and colorectal cancers. Sulforaphane… read more here.
Keywords: sulforaphane anticancer; synergistic effects; delivery; anticancer molecule ... See more keywords
Kinetic study of sulforaphane stability in blanched and un-blanched broccoli (Brassica oleracea var. italica) florets during storage at low temperatures
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DOI: 10.1007/s13197-018-3395-4
Abstract: Sulforaphane is a health-promoting compound found in broccoli. Given its high thermo-lability, its preservation through high-temperature processes seems inconvenient. Accordingly, storage at low temperature is an alternative. There are no studies about the evolution of… read more here.
Keywords: sulforaphane content; blanched blanched; low temperatures; blanched broccoli ... See more keywords
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins.
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DOI: 10.1016/j.carbpol.2017.12.022
Abstract: Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its clinical use. In order to circumvent… read more here.
Keywords: stabilization; sfn; study; inclusion complexes ... See more keywords
Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti‐inflammatory capacity in a cellular model of Alzheimer's disease
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DOI: 10.1016/j.ejphar.2018.01.046
Abstract: &NA; Sulforaphane was reported to exert neuroprotective effects via upregulating expression of nuclear factor erythroid 2‐related factor 2 (Nrf2) and has received increasing attention as an alternative candidate for treatment of Alzheimer's disease (AD). However,… read more here.
Keywords: alzheimer disease; cellular model; bgr decrease; decrease ... See more keywords
Glucoraphanin and sulforaphane evolution during juice preparation from broccoli sprouts.
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DOI: 10.1016/j.foodchem.2018.06.089
Abstract: Broccoli sprouts are considered functional food as they are naturally enriched in glucoraphanin (GR) that is the biological precursor of the anticancer compound sulforaphane (SFN). Due to its health promoting value, also broccoli sprout juice… read more here.
Keywords: sulforaphane; broccoli sprouts; juice; juice preparation ... See more keywords
The effect of processing and cooking on glucoraphanin and sulforaphane in brassica vegetables.
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DOI: 10.1016/j.foodchem.2021.130007
Abstract: Brassica vegetables are widely consumed mostly after processing and cooking. These processing and cooking methods not only can affect the taste, texture, flavor and nutrients of these vegetables, but also influence the levels of some… read more here.
Keywords: effect processing; glr slr; processing cooking; sulforaphane ... See more keywords
Dr. Jekyll and Mr. Hyde: Oxidizable phenol‐generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.06.039
Abstract: Abstract The transcription factor Nrf2 is a master regulator of antioxidant and cytoprotective genes, binding to antioxidant response elements (AREs) in their promoter regions. Due to the therapeutic role of the Nrf2/ARE system in oxidative… read more here.
Keywords: accumulation; nrf2 protein; dtbhq; expression ... See more keywords
Microwave pretreatment enhances the formation of cabbage sulforaphane and its bioaccessibility as shown by a novel dynamic soft rat stomach model
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DOI: 10.1016/j.jff.2018.02.009
Abstract: Abstract Microwave (MW) pretreatment was used to increase the sulforaphane content in cabbages. In vitro digestion in rat stomach and shaking flask was then investigated to monitor the bioaccessible sulforaphane content in the pretreated cabbages.… read more here.
Keywords: sulforaphane; rat stomach; digestion; microwave pretreatment ... See more keywords
Sulforaphane attenuates bisphenol A-induced 3T3-L1 adipocyte differentiation through cell cycle arrest
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DOI: 10.1016/j.jff.2018.02.021
Abstract: Abstract Bisphenol A (BPA) may be a critical risk factor for metabolic disorders including obesity and diabetes. Sulforaphane is known to inhibit adipocyte differentiation and induce adipocyte lipolysis. This study sought to investigate the possible… read more here.
Keywords: cycle; sulforaphane; adipocyte differentiation; cell cycle ... See more keywords