Synthesis of 3-O-Sulfated Heparan Sulfate Oligosaccharides Using 3-O-Sulfotransferase Isoform 4.
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DOI: 10.1021/acschembio.1c00474
Abstract: Heparan sulfate (HS) 3-O-sulfotransferase isoform 4 (3-OST-4) is a specialized carbohydrate sulfotransferase participating in the biosynthesis of heparan sulfate. Here, we report the expression and purification of the recombinant 3-OST-4 enzyme and use it for… read more here.
Keywords: sulfotransferase; sulfotransferase isoform; synthesis; heparan sulfate ... See more keywords
Novel topical booster enhances follicular sulfotransferase activity in patients with androgenetic alopecia: a new strategy to improve minoxidil response
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DOI: 10.1111/jdv.16645
Abstract: Topical minoxidil has been used as a topical treatment for androgenetic alopecia (AGA) for more than 30 years. Approximately 60 to 70% of patients do not achieve hair growth. Minoxidil is a pro-drug. In order… read more here.
Keywords: minoxidil; androgenetic alopecia; minoxidil response; sulfotransferase ... See more keywords
Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss
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DOI: 10.1111/jdv.16765
Abstract: Minoxidil is an antihypertensive agent and hair growth promoter. Minoxidil is a pro-drug that requires conversion to minoxidil sulfate by the sulfotransferase enzymes to be biologically active. Previously, we identified the sulfotransferases isoenzyme SULT1A1 as… read more here.
Keywords: minoxidil; hair; sulfotransferase enzyme; enzyme sult1a1 ... See more keywords
The Environmental Pollutant Bromophenols Interfere With Sulfotransferase That Mediates Endocrine Hormones
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DOI: 10.3389/fendo.2021.814373
Abstract: Bromophenols (BPs), known as an important environmental contaminant, can cause endocrine disruption and other chronic toxicity. The study aimed to investigate the potential inhibitory capability of BPs on four human sulfotransferase isoforms (SULT1A1, SULT1A3, SULT1B1… read more here.
Keywords: sult isoforms; sulfotransferase; inhibition; environmental pollutant ... See more keywords
Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes
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DOI: 10.3390/pharmaceutics11070355
Abstract: Catalposide, an active component of Veronica species such as Catalpa ovata and Pseudolysimachion lingifolium, exhibits anti-inflammatory, antinociceptic, anti-oxidant, hepatoprotective, and cytostatic activities. We characterized the in vitro metabolic pathways of catalposide to predict its pharmacokinetics.… read more here.
Keywords: udp glucuronosyltransferase; catalposide; carboxylesterase; sulfotransferase ... See more keywords