Mammalian iron sulfur cluster biogenesis and human diseases
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2597
Abstract: Fe-S cluster biogenesis is a multistep process that involves a complex sequence of catalyzed protein– protein interactions and coupled conformational changes between the components of several dedicated multimeric complexes. Intensive studies of the assembly process… read more here.
Keywords: mammalian iron; cluster biogenesis; biogenesis; sulfur cluster ... See more keywords
Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.04.007
Abstract: Iron‑sulfur clusters are essential cofactors found across all domains of life. Their assembly and transfer are accomplished by highly conserved protein complexes and partners. In eukaryotes a [2Fe-2S] cluster is first assembled in the mitochondria… read more here.
Keywords: cluster; iron sulfur; monothiol glutaredoxin; iron ... See more keywords
Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron–sulfur cluster assembly
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DOI: 10.1039/d2sc04169c
Abstract: Iron–sulfur (Fe–S) clusters are cofactors essential for life. Though the proteins that function in the assembly of Fe–S clusters are well known, details of the molecular mechanism are less well established. The Isc (iron–sulfur cluster)… read more here.
Keywords: iron; cluster assembly; sulfur; sulfur cluster ... See more keywords
The Suf Iron-Sulfur Cluster Biosynthetic System Is Essential in Staphylococcus aureus, and Decreased Suf Function Results in Global Metabolic Defects and Reduced Survival in Human Neutrophils
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DOI: 10.1128/iai.00100-17
Abstract: ABSTRACT Staphylococcus aureus remains a causative agent for morbidity and mortality worldwide. This is in part a result of antimicrobial resistance, highlighting the need to uncover novel antibiotic targets and to discover new therapeutic agents.… read more here.
Keywords: staphylococcus aureus; iron sulfur; sulfur; cluster ... See more keywords
Maturation and Assembly of Iron-Sulfur Cluster-Containing Subunits in the Mitochondrial Complex I From Plants
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DOI: 10.3389/fpls.2022.916948
Abstract: In plants, the mitochondrial complex I is the protein complex encompassing the largest number of iron-sulfur (Fe-S) clusters. The whole, membrane-embedded, holo-complex is assembled stepwise from assembly intermediates. The Q and N modules are combined… read more here.
Keywords: mitochondrial complex; maturation assembly; cluster; sulfur cluster ... See more keywords