Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.07.060
Abstract: Graphical abstract Figure. No Caption available. Abstract Sulindac loaded poly(HEMA) cross‐linked microparticles were synthesized via one‐pot free‐radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO)… read more here.
Keywords: carbon dioxide; sulindac; poly hema; supercritical carbon ... See more keywords
Insight into the colonic disposition of sulindac in humans.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.09.034
Abstract: NSAIDs such as celecoxib and sulindac play a critical role in the treatment of colorectal cancer, yet it is not understood how sufficiently high concentrations are reached in colonic tissue. We previously demonstrated that an… read more here.
Keywords: colonic disposition; sulindac; insight colonic; disposition sulindac ... See more keywords
Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-17-0230
Abstract: The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At… read more here.
Keywords: sulindac; colon; ras oncogene; mutant ras ... See more keywords
Sulindac induces differentiation of glioblastoma stem cells making them more sensitive to oxidative stress.
Sign Up to like & getrecommendations! Published in 2018 at "Neoplasma"
DOI: 10.4149/neo_2018_170404n245
Abstract: Glioblastoma tumors (GBM) are very heterogeneous, being comprised of several cell subtypes, including glioblastoma stem cells (GSC). These tumors have a high rate of recurrence after initial treatment and one of the most prevalent theories… read more here.
Keywords: sulindac; differentiation; stem; stem cells ... See more keywords