Synthesis and biological evaluation of pyrimidinyl sulphonamide derivatives as promising class of antitubercular agents
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DOI: 10.1016/j.jscs.2015.05.007
Abstract: Abstract A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2′,4′-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide F b and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide D b were found to be the most… read more here.
Keywords: sulphonamide derivatives; biological evaluation; pyrimidinyl sulphonamide; evaluation pyrimidinyl ... See more keywords
Evaluation of sulphonamide derivatives acting as inhibitors of human carbonic anhydrase isoforms I, II and Mycobacterium tuberculosisβ-class enzyme Rv3273
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DOI: 10.1080/14756366.2018.1471475
Abstract: Abstract A series of novel sulphonamide derivatives was obtained from sulphanilamide which was N4-alkylated with ethyl bromoacetate followed by reaction with hydrazine hydrate. The hydrazide obtained was further reacted with various aromatic aldehydes. The novel… read more here.
Keywords: carbonic anhydrase; human carbonic; sulphonamide derivatives; anhydrase isoforms ... See more keywords
Development of Praziquantel sulphonamide derivatives as antischistosomal drugs
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DOI: 10.1080/14756366.2022.2078970
Abstract: Abstract The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus Schistosoma, except Praziquantel (PZQ), urged to find new alternatives to fight this infection. Carbonic Anhydrase from… read more here.
Keywords: sulphonamide derivatives; praziquantel sulphonamide; derivatives antischistosomal; sulphonamide ... See more keywords