Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
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DOI: 10.1039/d1ra08220e
Abstract: Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a… read more here.
Keywords: synthesis; sulphonated graphene; continuous flow; graphene oxide ... See more keywords