Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes
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DOI: 10.1042/ebc20240030
Abstract: Abstract Cytosolic sulphotransferase (SULT) enzymes catalyse reactions involved in xenobiotic elimination and hormone regulation. However, SULTs can also generate electrophilic reactive intermediates from certain substrates, including the activation of carcinogens. Here, we review toxicological studies… read more here.
Keywords: toxification chemicals; mediated toxification; sulphotransferase mediated; sulphotransferase ... See more keywords
Age‐related change of hepatic uridine diphosphate glucuronosyltransferase and sulfotransferase activities in male chickens and pigs
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DOI: 10.1111/jvp.12355
Abstract: The hepatic activities of uridine diphosphate glucuronosyltransferase (UGT) and sulfotransferase (SULT) of male Ross 708 broiler chickens at the age of 1, 7, 14, 28, and 56 days and male Camborough-29 pigs at the age of… read more here.
Keywords: sult; uridine diphosphate; hepatic ugt; age ... See more keywords
PBPK Modeling of Acetaminophen in Pediatric Populations: Incorporation of SULT Enzyme Ontogeny to Predict Age-Dependent Metabolism and Systemic Exposure
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DOI: 10.3390/life15071099
Abstract: Sulfotransferase (SULT) enzymes contribute significantly to drug metabolism in pediatric patients. The purpose of this study was to develop a PBPK model for acetaminophen (APAP) in pediatric populations that accounts for the ontogeny of SULT… read more here.
Keywords: systemic exposure; pediatric populations; metabolism; pbpk modeling ... See more keywords