Distributed Cox proportional hazards regression using summary-level information.
Sign Up to like & getrecommendations! Published in 2022 at "Biostatistics"
DOI: 10.1093/biostatistics/kxac006
Abstract: Individual-level data sharing across multiple sites can be infeasible due to privacy and logistical concerns. This article proposes a general distributed methodology to fit Cox proportional hazards models without sharing individual-level data in multi-site studies.… read more here.
Keywords: level information; proportional hazards; level; cox proportional ... See more keywords
Meta-imputation of transcriptome from genotypes across multiple datasets by leveraging publicly available summary-level data
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009571
Abstract: Transcriptome wide association studies (TWAS) can be used as a powerful method to identify and interpret the underlying biological mechanisms behind GWAS by mapping gene expression levels with phenotypes. In TWAS, gene expression is often… read more here.
Keywords: summary level; expression; imputation; level data ... See more keywords