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   Articles with "sumo" as a keyword



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SUMO in Drosophila Development.

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recommendations! Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-319-50044-7_15

Abstract: The ubiquitin -like protein SUMO is conjugated covalently to hundreds of target proteins in organisms throughout the eukaryotic domain. Genetic and biochemical studies using the model organism Drosophila melanogaster are beginning to reveal many essential… read more here.

Keywords: target protein; drosophila development; sumo drosophila; biology ... See more keywords
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SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109485

Abstract: Structural maintenance of chromosomes (SMCs) complexes, cohesin, condensin, and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all… read more here.

Keywords: sumo chain; sumo protease; protease ulp2; smc complexes ... See more keywords
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SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.06.012

Abstract: Crossing over is essential for chromosome segregation during meiosis. Protein modification by SUMO is implicated in crossover control, but pertinent targets have remained elusive. Here we identify Msh4 as a target of SUMO-mediated crossover regulation.… read more here.

Keywords: sumo fosters; muts complex; fosters assembly; assembly functionality ... See more keywords
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PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells

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recommendations! Published in 2018 at "Heliyon"

DOI: 10.1016/j.heliyon.2018.e00709

Abstract: Gli-similar 3 (Glis3) is Krüppel-like transcription factor associated with the transcriptional regulation of insulin. Mutations within the Glis3 locus have been implicated in a number of pathologies including diabetes mellitus and hypothyroidism. Despite its clinical… read more here.

Keywords: function sumo; glis3 transactivation; pias family; transactivation function ... See more keywords
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SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.04.017

Abstract: The action of DNA topoisomerase II (Top2) creates transient DNA breaks that are normally concealed inside Top2-DNA covalent complexes. Top2 poisons, including ubiquitously present natural compounds and clinically used anti-cancer drugs, trap Top2-DNA complexes. Here,… read more here.

Keywords: dna; top2 dna; rrp2; dna translocase ... See more keywords
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SUMOylation Inhibition Mediated by Disruption of SUMO E1-E2 Interactions Confers Plant Susceptibility to Necrotrophic Fungal Pathogens.

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recommendations! Published in 2017 at "Molecular plant"

DOI: 10.1016/j.molp.2017.01.007

Abstract: Protein modification by SUMO modulates essential biological processes in eukaryotes. SUMOylation is facilitated by sequential action of the E1-activating, E2-conjugating, and E3-ligase enzymes. In plants, SUMO regulates plant development and stress responses, which are key… read more here.

Keywords: sumoylation; sumo conjugation; plant; inhibition ... See more keywords
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Structural and functional characterization of Tomato SUMO1 gene

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recommendations! Published in 2020 at "Saudi Journal of Biological Sciences"

DOI: 10.1016/j.sjbs.2019.10.004

Abstract: Small ubiquitin-related modifier (SUMO) genes regulate various functions of target proteins through post-translational modification. The SUMO proteins have a similar 3-dimensional structure as that of ubiquitin proteins and occur through a cascade of enzymatic reactions.… read more here.

Keywords: sumo1 gene; sls sumo1; tomato; structural functional ... See more keywords
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Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2018.12.011

Abstract: Rheumatoid arthritis (RA) is featured by erosive cartilage and bone destruction. The enhancing aggressive property of fibroblast-like synoviocytes (FLSs) plays a critical role in this process. Small ubiquitin-like modifier (SUMO) proteins, including SUMO-1, SUMO-2, SUMO-3… read more here.

Keywords: migration; role; rheumatoid arthritis; migration invasion ... See more keywords
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Standard binding free energy of a SIM SUMO complex.

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recommendations! Published in 2019 at "Journal of chemical theory and computation"

DOI: 10.1021/acs.jctc.9b00428

Abstract: Interaction of the small ubiquitin related modifier (SUMO) and peptides containing a SUMO interacting motif (SIM) attracted a lot of interest in recent years, yet their structural properties and relation between composition of the peptide… read more here.

Keywords: energy; standard binding; binding free; sim ... See more keywords

Site-Specific Protein Ubiquitylation Using an Engineered, Chimeric E1 Activating Enzyme and E2 SUMO Conjugating Enzyme Ubc9

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recommendations! Published in 2022 at "ACS Central Science"

DOI: 10.1021/acscentsci.1c01490

Abstract: Ubiquitylation—the attachment of ubiquitin (Ub) to proteins in eukaryotic cells—involves a vast number of enzymes from three different classes, resulting in heterogeneous attachment sites and ubiquitin chains. Recently, we introduced lysine acylation using conjugating enzymes… read more here.

Keywords: conjugating enzyme; sumo conjugating; enzyme ubc9; site specific ... See more keywords
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SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death

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recommendations! Published in 2017 at "Cell Death and Differentiation"

DOI: 10.1038/cdd.2017.29

Abstract: Nuclear receptor NR4A1 has been implicated as a key regulator in a wide range of pathophysiological responses. As an immediate early response gene, NR4A1 can be rapidly and potently induced by a variety of stimuli.… read more here.

Keywords: macrophage cell; ubiquitination nr4a1; nr4a1; cell death ... See more keywords