The SUMO Pathway in Mitosis.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-50044-7_10
Abstract: Mitosis is the stage of the cell cycle during which replicated chromosomes must be precisely divided to allow the formation of two daughter cells possessing equal genetic material. Much of the careful spatial and temporal… read more here.
Keywords: sumo pathway; pathway mitosis; mitosis; biology ... See more keywords
Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2025 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-025-05336-6
Abstract: Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft tissue sarcoma with limited therapeutic options, particularly for cases resistant to conventional treatments. The SUMOylation pathway, which plays a key role in regulating the cell cycle, apoptosis,… read more here.
Keywords: tak 981; sumo pathway; cell lines; sumoylation ... See more keywords
Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21954
Abstract: Cancer stem cells (CSCs) are expanded in anaplastic thyroid cancer (ATC) and standard treatment approaches have failed to improve survival, suggesting a need to specifically target the CSC population. Recent studies in breast and colorectal… read more here.
Keywords: sumo inhibitors; sumo pathway; treatment; cancer ... See more keywords
The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.940449
Abstract: Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition… read more here.
Keywords: ubc9 sumo; neck cancer; cleavage; head neck ... See more keywords
The SUMO Pathway in Hematomalignancies and Their Response to Therapies
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DOI: 10.3390/ijms20163895
Abstract: SUMO (Small Ubiquitin-related MOdifier) is a post-translational modifier of the ubiquitin family controlling the function and fate of thousands of proteins. SUMOylation is deregulated in various hematological malignancies, where it participates in both tumorigenesis and… read more here.
Keywords: sumoylation; pathway hematomalignancies; response; hematomalignancies response ... See more keywords
SUMO pathway is required for ribosome biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "BMB Reports"
DOI: 10.5483/bmbrep.2022.55.11.130
Abstract: Ribosomes, acting as the cellular factories for protein production, are essential for all living organisms. Ribosomes are composed of both proteins and RNAs and are established through the coordination of several steps, including transcription, maturation… read more here.
Keywords: sumo pathway; ribosome biogenesis; biogenesis; required ribosome ... See more keywords