A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.12.010
Abstract: The accumulation of α-synuclein amyloid fibrils in the brain is linked to Parkinson's disease and other synucleinopathies. The intermediate species in the early aggregation phase of α-synuclein are involved in the emergence of amyloid toxicity… read more here.
Keywords: synuclein aggregation; aggregation; sumo1; sumo1 derived ... See more keywords
Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107187119
Abstract: Significance SUMO protein can decorate other proteins via a process called SUMOylation that can regulate toxicity of proteins linked to neurodegenerative diseases. The mutant huntingtin (mHTT) protein in Huntington disease (HD) degenerates nerve cells, and… read more here.
Keywords: deletion; huntington disease; mhtt; sumo1 ... See more keywords
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh1486
Abstract: Description Small-molecule degraders of SUMO1 induce its ubiquitination and degradation through binding of CAPRIN1 in tumor cells in vitro and in vivo. Degrading the undruggable Ubiquitination controls degradation of proteins and is an enticing therapeutic… read more here.
Keywords: molecule; degradation; molecule degraders; small molecule ... See more keywords
Embryonic Cells Redistribute SUMO1 upon Forced SUMO1 Overexpression
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.01856-19
Abstract: Embryonic stem (ES) cells exhibit unusual transcriptional, proteomic, and signal response profiles, reflecting their unusual needs for rapid differentiation and replication. The work reported here demonstrated that mouse embryonic cell lines did not tolerate the… read more here.
Keywords: conjugation; overexpression; sumo1; overexpression sumo1 ... See more keywords
Commentary: Analysis of SUMO1-conjugation at synapses
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00345
Abstract: A commentary on Analysis of SUMO1-conjugation at synapses by Daniel, J. A., Cooper, B. H., Palvimo, J. J., Zhang, F. P., Brose, N., and Tirard, M. (2017). eLife 6:e26338. doi: 10.7554/eLife.26338 There is a large… read more here.
Keywords: conjugation synapses; commentary analysis; analysis sumo1; sumo1 ... See more keywords
The Molecular Simulation Study of nNOS Activation Induced by the Interaction Between Its Calmodulin-Binding Domain and SUMO1
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.535494
Abstract: Neuronal nitric oxide synthase (nNOS), an enzyme required for learning and memory, catalyzes L-arginine decomposition during nitric oxide production in mammalian neurons. Over-activation of nNOS leads to oxidative/nitrosative stress, which is part of the pathophysiological… read more here.
Keywords: binding domain; sumo1; study; activation ... See more keywords