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   Articles with "sumo2" as a keyword



Characterizing the Conformational Dynamics of Human SUMO2: Insights into its Interaction with Metal Ions and SIMs

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recommendations! Published in 2024 at "ChemBioChem"

DOI: 10.1002/cbic.202400045

Abstract: SUMO (Small Ubiquitin‐like Modifiers) proteins are involved in a crucial post‐translational modification commonly termed as SUMOylation. In this work, we have investigated the native‐state conformational flexibility of human SUMO2 and its interaction with Cu2+ and… read more here.

Keywords: human sumo2; dynamics human; conformational dynamics; sumo2 ... See more keywords

Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2

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recommendations! Published in 2021 at "Molecular Cancer"

DOI: 10.1186/s12943-021-01409-4

Abstract: Background Circular RNAs (circRNAs) are widely expressed in human cells and are closely associated with cancer development. However, they have rarely been investigated in the context of nasopharyngeal carcinoma (NPC). Methods We screened a new… read more here.

Keywords: circrnf13; sumo2; nasopharyngeal carcinoma; proliferation metastasis ... See more keywords

Direct binding of RNF8 to SUMO2/3 promotes cell survival following DNA damage.

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recommendations! Published in 2017 at "Molecular medicine reports"

DOI: 10.3892/mmr.2017.7624

Abstract: Ring finger protein 8 (RNF8), an FHA/RING domain containing E3 ubiquitin ligase, is critical in supporting genome integrity by facilitating the assembly of multiple DNA repair proteins at DNA lesions following DNA damage. In the… read more here.

Keywords: following dna; rnf8; dna damage; sumo2 ... See more keywords

SUMOylation of Nuclear γ-Actin by SUMO2 supports DNA Damage Repair against Myocardial Ischemia-Reperfusion Injury

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.74407

Abstract: Myocardial infarction triggers oxidative DNA damage, apoptosis and adverse cardiac remodeling in the heart. Small ubiquitin-like modifier (SUMO) proteins mediate post-translational SUMOylation of the cardiac proteins in response to oxidative stress signals. Upregulation of isoform… read more here.

Keywords: sumo2; dna damage; sumoylation; actin ... See more keywords