MS‐based strategies for identification of protein SUMOylation modification
Sign Up to like & getrecommendations! Published in 2019 at "Electrophoresis"
DOI: 10.1002/elps.201900100
Abstract: Protein SUMOylation modification conjugated with small ubiquitin‐like modifiers (SUMOs) is one kind of PTMs, which exerts comprehensive roles in cellular functions, including gene expression regulation, DNA repair, intracellular transport, stress responses, and tumorigenesis. With the… read more here.
Keywords: sumoylation; protein sumoylation; based strategies; sumoylation modification ... See more keywords
Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31881
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD), characterized by aberrant triglycerides accumulation in liver, affects the metabolism remodeling of hepatic and non-hepatic tissues by secreting altered hepatokines. SUMO-specific protease 2 (SENP2) is responsible for… read more here.
Keywords: sumoylation; metabolism; liver adipose; senp2 ... See more keywords
Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23336
Abstract: Monocarboxylate transporter 4 (MCT4) is highly expressed in various types of solid neoplasms including breast cancer (BC); however, the pro‐tumor functions underlying its increased expression have not been explained. Here, we examined the roles of… read more here.
Keywords: sumoylation; mct4 sumoylation; mct4; breast cancer ... See more keywords
Sumoylation: Implications for Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-50044-7_16
Abstract: The covalent posttranslational modifications of proteins are critical events in signaling cascades that enable cells to efficiently, rapidly and reversibly respond to extracellular stimuli. This is especially important in the CNS where the processes affecting… read more here.
Keywords: sumoylation; sumoylation implications; neurodegenerative diseases; implications neurodegenerative ... See more keywords
Sumoylation and Its Contribution to Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-50044-7_17
Abstract: Post-translational modifications play an important role in regulating protein activity by altering their functions. Sumoylation is a highly dynamic process which is tightly regulated by a fine balance between conjugating and deconjugating enzyme activities. It… read more here.
Keywords: sumoylation; sumoylation contribution; contribution cancer; biology ... See more keywords
SUMO and SUMOylation in plant abiotic stress
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DOI: 10.1007/s10725-020-00624-1
Abstract: The post-translational modification is the fundamental reason for the most of the cellular signaling events. Plant shows meticulous response to survive in different environmental stresses. SUMOylation is one of the important post-translational modifications. Post-translational modifiers… read more here.
Keywords: sumoylation; growth development; plant; post translational ... See more keywords
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03260-x
Abstract: Paclitaxel is a common chemotherapeutic agent in cancer treatment, while it often causes chemotherapy-induced peripheral neuropathy (CIPN), which manifested as hyperalgesia and allodynia, and its mechanism remains largely unknown. The previous study has shown that matrix metalloproteinase-2 (MMP-2)… read more here.
Keywords: sumoylation; paclitaxel induced; induced neuropathic; neuropathic pain ... See more keywords
Antibody-free enrichment method for proteome-wide analysis of endogenous SUMOylation sites.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338324
Abstract: SUMOylation is a reversible post-translational modification that plays crucial roles in numerous cellular processes. Although anti-SUMO antibodies have been applied to analyze exogenous and endogenous SUMOylation, such immunoprecipitation enrichment strategy is applicable only for the… read more here.
Keywords: sumoylation; antibody free; enrichment; endogenous sumoylation ... See more keywords
SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.103
Abstract: The Unfolded Protein Response (UPR) is a cascade of intracellular stress signaling from the endoplasmic reticulum (ER) that protect the cells from the stress caused by accumulation of unfolded or misfolded proteins in the ER.… read more here.
Keywords: protein; sumoylation; atf6 protein; transcriptional activity ... See more keywords
Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.104
Abstract: SUMOylation, a post-translational modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD), and in neuron- and astrocyte-specific physiological functions. Global SUMOylation… read more here.
Keywords: sumoylation; alzheimer disease; alteration global; neurons astrocytes ... See more keywords
2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.079
Abstract: Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum… read more here.
Keywords: sumoylation; accumulation; myeloid leukemia; ros accumulation ... See more keywords