SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway.
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DOI: 10.1016/j.cellsig.2020.109686
Abstract: In cancers, apoptosis evasion through dysregulation of pro-apoptotic and anti-apoptotic intracellular signals is a recurring event. Accordingly, selective inhibition of specific proteins represents an exciting therapeutic opportunity. Myeloid cell leukemia 1 (MCL1) is an anti-apoptotic… read more here.
Keywords: protein; sumoylation mcl1; proteasome pathway; mcl1 ... See more keywords