Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
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DOI: 10.1016/j.celrep.2020.01.025
Abstract: SUMMARY Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,… read more here.
Keywords: cardiac myocytes; late sodium; sumoylation nav1; sodium current ... See more keywords