SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
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DOI: 10.1038/s41467-021-24802-5
Abstract: SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but not its… read more here.
Keywords: restriction; non cycling; sumoylation samhd1; cycling cells ... See more keywords