Homozygous deletion of SUN5 in three men with decapitated spermatozoa
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx200
Abstract: A recent study of 17 men with decapitated spermatozoa found that 8 carried two rare SUN5 alleles, and concluded that loss of SUN5 function causes the acephalic spermatozoa syndrome. Consistent with this, the SUN5 protein… read more here.
Keywords: men decapitated; sun5; spermatozoa; decapitated spermatozoa ... See more keywords
SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.684826
Abstract: Acephalic spermatozoa syndrome is a rare genetic and reproductive disease. Recent studies have shown that approximately 33–47% of patients with acephalic spermatozoa syndrome have SUN5 mutations, but the molecular mechanism underlying this phenomenon has not… read more here.
Keywords: sun5; head tail; mice; tail ... See more keywords
Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215368
Abstract: Simple Summary Globally, colorectal cancer (CRC) is one of the most common malignant tumors, and the SUN protein family regulates the proliferation and migration of tumors. However, the biological function and mechanism of SUN5 in… read more here.
Keywords: proliferation migration; proliferation; sun5; crc ... See more keywords