Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
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DOI: 10.1021/acs.jmedchem.8b01139
Abstract: Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity and mortality from excessive bleeding during surgery and after trauma. Current drugs used for inhibiting the dissolution of fibrin, the main structural component of blood clots,… read more here.
Keywords: highly potent; potent selective; inhibitor; trypsin inhibitor ... See more keywords