Protective Effect of RIVA Against Sunitinib-Induced Cardiotoxicity by Inhibiting Oxidative Stress-Mediated Inflammation: Probable Role of TGF-β and Smad Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-019-09551-8
Abstract: Sunitinib (SUN) is an oral tyrosine kinase inhibitor approved in 2006 as a first-line treatment for metastatic renal cell cancer. However, weak selectivity to kinase receptors and cardiotoxicity have limited the use of sunitinib. Rivaroxaban… read more here.
Keywords: induced cardiotoxicity; treatment; sunitinib induced; sunitinib ... See more keywords
Metformin Protects Against Sunitinib-induced Cardiotoxicity: Investigating the Role of AMPK
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001256
Abstract: Abstract: Sunitinib is associated with cardiotoxicity through inhibition of AMP-protein kinase (AMPK) signaling. By contrast, the common antidiabetic agent metformin has demonstrated cardioprotection through indirect AMPK activation. In this study, we investigate the effects of… read more here.
Keywords: sunitinib induced; sunitinib; cardiotoxicity; role ampk ... See more keywords
Abstract 4911: Metabolic activation of sunitinib: Implications for sunitinib-induced toxicities
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4911
Abstract: Purpose: Sunitinib is a multi-targeted tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. However, clinical use of sunitinib is associated with potentially fatal idiosyncratic liver… read more here.
Keywords: metabolic activation; sunitinib induced; sunitinib; gsh ... See more keywords
Sunitinib-Induced Acute Liver Failure
Sign Up to like & getrecommendations! Published in 2021 at "Case Reports in Gastroenterology"
DOI: 10.1159/000511249
Abstract: Drug-induced liver injury is an uncommon but life-threatening entity. Sunitinib is a tyrosine kinase inhibitor used for advanced and imatinib-refractory gastrointestinal stromal tumors. It causes transient elevation in liver enzymes. The incidence of fatal acute… read more here.
Keywords: liver failure; sunitinib induced; acute liver; liver ... See more keywords
Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
Sign Up to like & getrecommendations! Published in 2022 at "Case Reports in Oncology"
DOI: 10.1159/000521206
Abstract: Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recently,… read more here.
Keywords: sunitinib induced; hypopituitarism; related hypopituitarism; induced adrenal ... See more keywords
An Insight on the Pathways Involved in Crizotinib and Sunitinib Induced Hepatotoxicity in HepG2 Cells and Animal Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.749954
Abstract: Both crizotinib and sunitinib, novel orally-active multikinase inhibitors, exhibit antitumor activity and extend the survival of patients with a malignant tumor. However, some patients may suffer liver injury that can further limit the clinical use… read more here.
Keywords: sunitinib induced; crizotinib sunitinib; sunitinib; oxidative stress ... See more keywords
Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020308
Abstract: Abstract Sunitinib has been associated with several cardiotoxic effects such as cardiac fibrosis. The present study was designed to explore the role of interleukin (IL)-17 in sunitinib-induced myocardial fibrosis (MF) in rats and whether its… read more here.
Keywords: sunitinib induced; sunitinib; interstitial fibrosis; black garlic ... See more keywords
Sunitinib-Induced Congestive Heart Failure in a Patient with Gastrointestinal Stromal Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Iranian medicine"
DOI: 10.34172/aim.2022.64
Abstract: Common cardiovascular toxicities of sunitinib mainly include hypertension, QT prolongation, left ventricular dysfunction (LVD) and less frequently, congestive heart failure (CHF). Here, we report the case of a 67-year-old woman who developed heart failure after… read more here.
Keywords: sunitinib induced; congestive heart; heart failure; heart ... See more keywords