DIPG-34. SUPER ELONGATION COMPLEX AS A TARGETABLE DEPENDENCY IN H3K27M+ DIFFUSE MIDLINE GLIOMA
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DOI: 10.1093/neuonc/noaa222.082
Abstract: Abstract Mutations in the histone 3 gene (H3K27M) are the eponymous driver in diffuse intrinsic pontine gliomas (DIPGs) and other diffuse midline gliomas (DMGs), aggressive pediatric brain tumors for which no curative therapy currently exists.… read more here.
Keywords: diffuse; super elongation; h3k27m; elongation complex ... See more keywords
The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
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DOI: 10.1126/sciadv.adf0005
Abstract: MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-driven… read more here.
Keywords: mycn amplified; elongation; transcription elongation; super elongation ... See more keywords