Epigenomic features revealed by ATAC‐seq impact transgene expression in CHO cells
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27701
Abstract: Different regions of a mammalian genome have different accessibilities to transcriptional machinery. The integration site of a transgene affects how actively it is transcribed. Highly accessible genomic regions called super‐enhancers have been recently described as… read more here.
Keywords: integration; atac seq; cho cells; super enhancer ... See more keywords
Super enhancer‐LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24460
Abstract: Super enhancer‐lncRNA smooth muscle and endothelial cell‐enriched migration/differentiation‐associated lncRNA (SENCR) were highly overexpressed in cisplatin‐resistant A549/DDP cells, while the mechanism was unclear. read more here.
Keywords: lncrna sencr; enhancer lncrna; sencr promoted; super enhancer ... See more keywords
Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.016
Abstract: The relationship between promoter proximal transcription factor-associated gene expression and super-enhancer-driven transcriptional programs are not well defined. However, their distinct genomic occupancy suggests a mechanism for specific and separable gene control. We explored the transcriptional… read more here.
Keywords: control; super enhancer; multiple myeloma; promoter ... See more keywords
A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.10.093
Abstract: PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor cells achieve their expression remains to be addressed. Here, we find that PD-L1 and PD-L2 are co-expressed in cancer cell lines and… read more here.
Keywords: cancer; immune evasion; expression; super enhancer ... See more keywords
Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101857
Abstract: Summary Due to the lack of effective early diagnostic measures and treatment methods, bladder cancer has become a malignant tumor that seriously threatens people's lives and health. Here, we reported that LINC00162, a super-enhancer long… read more here.
Keywords: bladder cancer; bladder; expression; super enhancer ... See more keywords
Integrative functional analysis of super enhancer SNPs for coronary artery disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Human Genetics"
DOI: 10.1038/s10038-018-0422-2
Abstract: Clinical research in coronary artery disease (CAD) primarily focused on genetic variants located in protein-coding regions. Recently, mutations fall within non-coding regions have been suggested to be essential to the pathogenesis of human complex disease.… read more here.
Keywords: cad; disease; super enhancer; enhancer snps ... See more keywords
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24843-w
Abstract: Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore the mechanistic role of super-enhancers… read more here.
Keywords: cytokine; super enhancer; expression; alcoholic hepatitis ... See more keywords
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25862-3
Abstract: Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In… read more here.
Keywords: enhancer; super enhancer; site; ctcf ... See more keywords
Identification of a modular super-enhancer in murine retinal development
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27924-y
Abstract: Super-enhancers are expansive regions of genomic DNA comprised of multiple putative enhancers that contribute to the dynamic gene expression patterns during development. This is particularly important in neurogenesis because many essential transcription factors have complex… read more here.
Keywords: development; expression; retinal development; cell ... See more keywords
A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28666-1
Abstract: The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast Myosin genes. By 4C-seq we show… read more here.
Keywords: myosin heavy; super enhancer; fast myosin; myosin genes ... See more keywords
BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109133119
Abstract: Significance We found that BRD4 interacts with the LSD1/NuRD complex and colocalizes with this repressive complex on super-enhancers and that decommissioning BRD4-directed super-enhancer organization of transcription repression programs inflicts widespread drug resistance in breast cancer.… read more here.
Keywords: breast; breast cancer; enhancer organization; super enhancer ... See more keywords