Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
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DOI: 10.1073/pnas.2025030118
Abstract: Significance Heart disease is the leading cause of death worldwide, and hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, affecting over 1 in 200 people. Mutations in myosin, the motor protein… read more here.
Keywords: myosin; microscopy; relaxed state; mutation ... See more keywords