Investigations on Superbase Mediated Reactivity of N‐Tosylhydrazones with Aza‐ortho‐Quinone Methide Precursors
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DOI: 10.1002/ejoc.202400151
Abstract: We have encountered a superbase‐mediated chemoselective reaction of N‐tosylhydrazones with aza‐ortho‐quinone methide precursors. When tosylhydrazone was treated with ortho‐aminobenzyl alcohol in super basic conditions (KOH+DMSO), we observed the formation of 2‐substituted quinoline. The reaction was… read more here.
Keywords: aza ortho; ortho quinone; quinone methide; superbase mediated ... See more keywords
Superbase-Mediated gem-Difluoroalkenylations of Sulfoximines.
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DOI: 10.1021/acs.orglett.2c03046
Abstract: At ambient temperature, deprotonated sulfoximines react with 1-trifluoromethylalkenes to provide either N- or C-gem-difluoroalkenylated products. The reaction site depends upon the N substituent of the starting material. The optimal conditions involve the use of a… read more here.
Keywords: gem; mediated gem; difluoroalkenylations sulfoximines; superbase mediated ... See more keywords