Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
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DOI: 10.1093/nar/gkad190
Abstract: To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this complex is a requisite enzyme intermediate, it is also intrinsically dangerous to genomic stability. Consequently, cleavage… read more here.
Keywords: supercoil handedness; type topoisomerases; cleavage; dna ... See more keywords