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Published in 2025 at "PLOS Computational Biology"
DOI: 10.1101/2025.01.02.631060
Abstract: DNA supercoiling (SC), the over- and under-winding of DNA, is generated by transcription as described in the twin-domain model. Conversely, SC also impacts transcription through torsional stress. SC therefore regulates transcription independent of transcription factor…
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Keywords:
supercoiling level;
topological domains;
differential effect;
gene ... See more keywords