D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0433-3
Abstract: Chronic pain is a common and undertreated nonmotor symptom in Parkinson’s disease (PD). Although chronic pain is improved by L-dopa in some PD patients, the underlying mechanisms remain unclear. In this study, we established PD… read more here.
Keywords: pain hypersensitivity; superficial dorsal; mice; receptor ... See more keywords
Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81269-6
Abstract: Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal horn (SDH) requires further study. We used… read more here.
Keywords: bdnf simultaneously; superficial dorsal; dorsal horn; chronic bdnf ... See more keywords