Overall Survival and Quality-of-Life Superiority in Modern Phase 3 Oncology Trials: A Meta-Epidemiological Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2025.1002
Abstract: Importance Alternative end points, such as progression-free survival, are increasingly used in phase 3 randomized clinical trials (RCTs). However, alternative end points are often not valid surrogates for overall survival and quality of life (QOL)… read more here.
Keywords: oncology; end; qol; superiority ... See more keywords
Superiority of living animal models in microsurgical training: beyond technical expertise
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Plastic Surgery"
DOI: 10.1007/s00238-021-01798-1
Abstract: Many studies are investigating the role of living and nonliving models to train microsurgeons. There is controversy around which modalities account for the best microsurgical training. In this study, we aim to provide a systematic… read more here.
Keywords: superiority; non technical; microsurgical training; living nonliving ... See more keywords
Methodological aspects of superiority, equivalence, and non-inferiority trials
Sign Up to like & getrecommendations! Published in 2020 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-020-02450-9
Abstract: Depending on the scientific hypothesis to be addressed, randomized-controlled trials (RCT) are accordingly designed. RCTs that aim to determine whether a novel, experimental therapeutic intervention (either a drug or a treatment) is superior to a… read more here.
Keywords: intervention; superiority; equivalence non; non inferiority ... See more keywords
Cognitive and neural markers of super-recognisers’ face processing superiority and enhanced cross-age effect
Sign Up to like & getrecommendations! Published in 2018 at "Cortex"
DOI: 10.1016/j.cortex.2018.07.008
Abstract: Super-recognisers inhabit the extreme high end of an adult face processing ability spectrum in the population. While almost all research in this area has evaluated those with poor or mid-range abilities, evaluating whether super-recognisers' superiority… read more here.
Keywords: superiority; cross age; age; recognition ... See more keywords
The effect of information superiority on a supply chain of virtual products
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Production Economics"
DOI: 10.1016/j.ijpe.2019.07.004
Abstract: Abstract Virtual products, such as mobile apps, 3D print files, e-music, etc., are produced with ample capacity and supplied with zero lead-time. We consider a two-echelon supply chain of a virtual product whose parties, a… read more here.
Keywords: retailer; manufacturer; information superiority; virtual products ... See more keywords
Is a filled lateral canal – A sign of superiority?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dental Sciences"
DOI: 10.1016/j.jds.2020.02.009
Abstract: Three-dimensional disinfection is more important than three-dimensional obturation. This letter refreshes and re-emphasizes various concepts on filling lateral canals and apical ramifications. Several questions on the importance of filling these accessory innervations if any, beneficial… read more here.
Keywords: superiority; filling accessory; lateral canal; root canal ... See more keywords
Origins of the Superiority of Oscillating Electric Fields for Disrupting Senile Plaques: Insights from the 7-Residue Fragment and the Full-length Aβ-42 Peptide
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c14791
Abstract: Our recent molecular dynamics simulations of decomposing Alzheimer’s disease plaques, under oscillating- and static external electric fields (Os-EEFs and St-EEFs), revealed the superiority of Os-EEF for decomposing plaques consisting of the 7-residue peptide segment. This… read more here.
Keywords: electric fields; eef; peptide; superiority ... See more keywords
Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein: in vitro characterization, ex vivo permeation and in vivo skin deposition study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2018.1430831
Abstract: Abstract Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence,… read more here.
Keywords: transdermal delivery; superiority; niosomes transdermal; novel bilosomes ... See more keywords
A confirmatory basket design considering non-inferiority and superiority testing.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2192781
Abstract: For multiple rare diseases as defined by a common biomarker signature, or a disease with multiple disease subtypes of low frequency, it is often possible to provide confirmatory evidence for these disease or subtypes (baskets)… read more here.
Keywords: inferiority; non inferiority; confirmatory basket; design ... See more keywords
A SYSTEMATIC REVIEW OF SUPERIORITY TRIALS TO ELUCIDATE THE CONCEPT OF SUPERIORITY MARGIN
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000571368.66685.36
Abstract: Objective:Progress towards superiority trial design and analysis has been slow. A statistically significant result may not be clinically relevant. In this study, we aimed to show that overpowered trials show statistical significance sans clinical relevance.Design… read more here.
Keywords: trials elucidate; elucidate concept; superiority trials; systematic review ... See more keywords
The inferiority of noninferiority trials
Sign Up to like & getrecommendations! Published in 2020 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.15592
Abstract: Noninferiority trials are increasingly popular in surgical literature. They aim to demonstrate that a new treatment is no worse than an existing treatment but may have added benefits. Their design is, in many ways, counterintuitive… read more here.
Keywords: intervention; superiority; null hypothesis; control ... See more keywords