Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12777
Abstract: Here, we found that formate, an essential one‐carbon metabolite, activates superoxide ( O2·− )/hydrogen peroxide (H2O2) release from mitochondria. Sodium formate (30 μm) induces a significant increase in O2·− /H2O2 production in liver mitochondria metabolizing… read more here.
Keywords: hydrogen peroxide; liver mitochondria; superoxide hydrogen; h2o2 ... See more keywords
Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20190305
Abstract: Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria-targeted antioxidants such… read more here.
Keywords: hydrogen; site; use s1qels; superoxide hydrogen ... See more keywords
Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2017-0284
Abstract: Abstract Mitochondrial 2-oxoacid dehydrogenase complexes oxidize 2-oxoglutarate, pyruvate, branched-chain 2-oxoacids and 2-oxoadipate to the corresponding acyl-CoAs and reduce NAD+ to NADH. The isolated enzyme complexes generate superoxide anion radical or hydrogen peroxide in defined reactions… read more here.
Keywords: hydrogen peroxide; oxoacid dehydrogenase; dehydrogenase complexes; superoxide hydrogen ... See more keywords