Addressing reproducibility in single-laboratory phenotyping experiments
Sign Up to like & getrecommendations! Published in 2017 at "Nature Methods"
DOI: 10.1038/nmeth.4259
Abstract: high resolution MS data directly onto pathways, (ii) cross-integration of genomic and proteomic data and (iii) metabolite identity verification via data-dependent MS/MS analysis, either separately or as part of the autonomous workflow5. Our multi-omic analysis… read more here.
Keywords: integration; analysis; supplementary fig; study ... See more keywords
SHP1 regulates a STAT6–ITGB3 axis in FLT3ITD-positive AML cells
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0676-5
Abstract: Acute myeloid leukemia (AML) is a life-threatening disease with limited treatment opportunities. FMS-like tyrosine kinase 3 with internal tandem duplications (FLT3ITD) is a constitutively active receptor tyrosine kinase, found in 25–30% of AML cases and… read more here.
Keywords: shp1 depletion; supplementary fig; disease; shp1 ... See more keywords
Baricitinib prevents GvHD by increasing Tregs via JAK3 and treats established GvHD by promoting intestinal tissue repair via EGFR
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01360-9
Abstract: TO THE EDITOR Graft-vs-host disease (GvHD) is the major cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) [1]. We were the first to report that pharmacologic inhibition of Janus kinases… read more here.
Keywords: vehicle control; bari; supplementary fig;
HIF-1α and HDAC1 mediated regulation of FAM99A-miR92a signaling contributes to hypoxia induced HCC metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00223-6
Abstract: Dear Editor, Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers. Previous studies have shown that many protein-coding genes and microRNAs are regulated upon hypoxia and involved in the progression of… read more here.
Keywords: hcc; supplementary fig; expression; fam99a ... See more keywords
Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00229-0
Abstract: Dear Editor, Dishevelled-2 (DVL2) is a central adaptor protein that propagates signals from upstream receptors to downstream effector β-catenin in canonical Wnt signaling. At high local concentration, DVL2 assembles into signalosomes through DIX domain-mediated homo-polymerization… read more here.
Keywords: acetylation; puncta; supplementary fig; formation ... See more keywords
Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00281-w
Abstract: Dear Editor, Colorectal cancer (CRC) is one of the most frequent diseases with high mortality around the world. Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,… read more here.
Keywords: apoptosis; supplementary fig; trifolirhizin; mtor ... See more keywords
Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00353-x
Abstract: Dear Editor, The ongoing outbreak of pneumonia (coronavirus disease 2019, COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health emergency. Scutellaria Baicalensis Georgi extract, a Traditional Chinese Medicine (TCM) widely… read more here.
Keywords: mptp; baicalein; inhibition; supplementary fig ... See more keywords
Adiponectin exacerbates influenza infection in elderly individuals via IL-18
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DOI: 10.1038/s41392-020-0141-y
Abstract: Dear Editor, Influenza affects humans of all ages; however, elderly people have increased susceptibility to infections and are especially predisposed to complications. A number of global efforts have increased influenza vaccination administration in elderly people… read more here.
Keywords: infection; supplementary fig; influenza infection; adiponectin ... See more keywords
PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00463-0
Abstract: Dear Editor, Programmed death ligand-1 (PD-L1) is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells, inhibits T cell activity and proliferation, facilitates cancer cells to… read more here.
Keywords: supplementary fig; genomic stability; sa1; interaction ... See more keywords
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00474-x
Abstract: Dear Editor, The loss of PINK1/Parkin-dependent mitochondrial clearance causes loss of dopaminergic neurons in the substantia nigra and contributes to the pathogenesis of Parkinson’s disease (PD). Several kinases were reported to regulate the ubiquitin E3… read more here.
Keywords: shp2; supplementary fig; fig supplementary; fig ... See more keywords
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00489-4
Abstract: Dear Editor, Gastric cancer (GC) is among the most prevalent gastrointestinal malignancies. The occurrence of local deep infiltration or distant metastasis in GC is commonly associated with weak treatment and poor prognosis. Although, N4-Acetylcytidine (ac4C)… read more here.
Keywords: nat10; supplementary fig; metastasis; expression ... See more keywords