HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia
Sign Up to like & getrecommendations! Published in 2019 at "Protein & Cell"
DOI: 10.1007/s13238-019-0627-y
Abstract: β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%,… read more here.
Keywords: monkey; hbb; information fig; thalassemia ... See more keywords
Structural insight into the Zika virus capsid encapsulating the viral genome
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DOI: 10.1038/s41422-018-0007-9
Abstract: Dear Editor, In 2015, a Zika virus (ZIKV) outbreak began in South and Central America and in the Caribbean, and has since spread to both North America and Asia. It has been revealed that ZIKV… read more here.
Keywords: protein; information figure; zikvcc; supplementary information ... See more keywords
Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0060-4
Abstract: Dear Editor, The tumor-microenvironment interactions play important roles in tumor progression, metastasis, and therapeutic resistance, and increasing evidence indicates that tumor cellderived exosomes can systematically modulate or reprogram the tumor microenvironment by transferring molecules, such… read more here.
Keywords: cell; information figure; supplementary information; tumor ... See more keywords
Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0114-7
Abstract: Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to… read more here.
Keywords: ciliogenesis; information fig; supplementary information; glcnacylation ... See more keywords
Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome
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DOI: 10.1038/s41422-019-0146-7
Abstract: Dear Editor, Histone marks deposited by post-translational modifications (PTMs) frequently occur in interrelated combinational patterns to create a complex and precise control on the chromatin structure and function. One of the landmark findings of histone… read more here.
Keywords: surface; supplementary information; h2b; fig ... See more keywords
Structural insights into the activation of ATM kinase
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DOI: 10.1038/s41422-019-0205-0
Abstract: Dear Editor, ATM (ataxia telangiectasia-mutated) is a master regulator in response to DNA damage and activates downstream pathways involved in cell cycle checkpoints, DNA damage repair, transcription regulation, immune response, central nervous system development and… read more here.
Keywords: kinase; dimer; supplementary information; fig ... See more keywords
Cryo-EM structure of human lysosomal cobalamin exporter ABCD4
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DOI: 10.1038/s41422-019-0222-z
Abstract: Dear Editor, Cobalamin, also known as vitamin B12, can only be biosynthesized by certain bacteria and archaea. As an essential nutrient for humans, it should be obtained from daily food. Exogenous cobalamin is taken up… read more here.
Keywords: supplementary information; abcd4; structure; fig ... See more keywords
Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1
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DOI: 10.1038/s41422-019-0233-9
Abstract: Dear Editor, DNA N-methyladenine (6mA) modification is common in prokaryotes and eukaryotes, involving in gene regulation, transposon, stem cell differentiation, and human tumors. At present, it has been confirmed that 6mA is ubiquitous in the… read more here.
Keywords: halkbh1; demethylation; supplementary information; fig ... See more keywords
The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes
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DOI: 10.1038/s41422-020-0292-y
Abstract: Dear Editor, Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) are of significant translational value to in vitro studies of human cardiac development, drug and cardiotoxicity testing and cardiac disease modelling. Differentiation of hPSCs to CMs,… read more here.
Keywords: cd36; information fig; cms; supplementary information ... See more keywords
Mitochondrial replacement in macaque monkey offspring by first polar body transfer
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DOI: 10.1038/s41422-020-0381-y
Abstract: Dear Editor, Mitochondrial DNA (mtDNA) mutations are maternally inherited to the offspring and mitochondrial replacement therapy (MRT) provides a promising approach for preventing mtDNA-related diseases. First polar body transfer (PB1T) has been used for mitochondrial… read more here.
Keywords: monkey; pb1; supplementary information; scc ... See more keywords
Structural insights into the activation of GLP-1R by a small molecule agonist
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DOI: 10.1038/s41422-020-0384-8
Abstract: Dear Editor, The glucagon-like peptide-1 receptor (GLP-1R) belongs to class B G protein-coupled receptors (GPCRs). It is a clinically proven target for type 2 diabetes and obesity. Several peptidic drugs have been approved including one… read more here.
Keywords: glp; agonist; small molecule; supplementary information ... See more keywords