Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway
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DOI: 10.1002/ddr.22021
Abstract: Urolithin A (UA) is a microbial metabolite of natural polyphenols ellagitannins and ellagic acid with well‐established antitumor properties against various malignancies. However, the exact role of UA in gastric cancer (GC) progression remains largely unclear.… read more here.
Keywords: tumor progression; suppresses tumor; gastric cancer; urolithin suppresses ... See more keywords
USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2
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DOI: 10.1126/sciadv.abc9730
Abstract: USP15 deubiquitinase inactivates TET2 to suppress tumor immunity and is a potential therapeutic target of immunotherapy. TET2 DNA dioxygenase is frequently mutated in human hematopoietic malignancies and functionally inactivated in many solid tumors through a… read more here.
Keywords: tet2 usp15; suppresses tumor; tumor immunity; tet2 ... See more keywords