Adipokine gremlin‐1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy‐mediated signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30982
Abstract: Gremlin‐1 (GR1) is a novel adipokine that is highly expressed in human adipocytes and has been shown to inhibit the BMP2/4‐TGFb signaling pathway. It has an effect on insulin sensitivity. Elevated levels of Gremlin have… read more here.
Keywords: stress; suppressing autophagy; stress suppressing; gr1 ... See more keywords
FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00856-9
Abstract: Since microglia-associated neuroinflammation plays a pivotal role in the progression of white matter diseases, modulating microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of fingolimod (FTY720) on… read more here.
Keywords: anti inflammatory; fty720; via stat1; autophagy via ... See more keywords
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.921394
Abstract: Stroke remains one of the leading reasons of mortality and physical disability worldwide. The treatment of cerebral ischemic stroke faces challenges, partly due to a lack of effective treatments. In this study, we demonstrated that… read more here.
Keywords: mtor phosphorylation; autophagy via; ampk mtor; suppressing autophagy ... See more keywords