Articles with "suppressing kras" as a keyword



Photo from wikipedia

Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma.

Sign Up to like & get
recommendations!
Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00986

Abstract: The interaction between son of sevenless 1 (SOS1) gene and Kirsten rat sarcoma viral oncogene (KRAS) is crucial for activating signals of proliferation and survival in a range of cancers. We previously discovered compound 40a… read more here.

Keywords: bioavailable sos1; orally bioavailable; kras driven; suppressing kras ... See more keywords