Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs‐MDSCs in newborns
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4hi0921-514rr
Abstract: Transitory appearance of immune suppressive polymorphonuclear neutrophils (PMNs) defined as myeloid‐derived suppressor cells (PMNs‐MDSCs) in newborns is important for their protection from inflammation associated with newly established gut microbiota. Here, we report that inhibition of… read more here.
Keywords: mdscs newborns; pmns mdscs; suppressive activity; immune suppressive ... See more keywords
Suppressive activity of Vδ2+ γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02469-8
Abstract: Despite recent progress in the understanding of γδ T cells’ roles and functions, their interaction with αβ T cells still remains to be elucidated. In this study, we sought to clarify what precisely endows peripheral… read more here.
Keywords: strength; activity; cells licensed; suppressive activity ... See more keywords
Synergistic effect of adoptive immunotherapy and docetaxel inhibits tumor growth in a mouse model.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2019.104036
Abstract: Adoptive T cell transfer therapy (ACT) has emerged as a promising approach to cancer immunotherapy; however, the efficacy of ACT is limited by the T-cell suppressive activity of myeloid-derived suppressor cells (MDSCs), which accumulate in… read more here.
Keywords: tumor; act; docetaxel inhibits; suppressive activity ... See more keywords
Plant Growth Suppressive Activity of (R)-3-(7'-Aryl-9'-hydroxyprop-8'-yl)coumarin, Structural Isomer of Z-2-Hydroxybenzylidene-γ-butyrolactone-type Lignan.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01926
Abstract: 3-(7'-Aryl-9'-hydroxyprop-8'-yl)coumarin, which is a structural isomer of a Z-2-hydroxybenzylidene-γ-butyrolactone-type lignan, was stereoselectively synthesized and subjected to plant growth regulation examination. (R)-4'-Methoxyphenyl derivative 3 showed stereospecific plant growth suppressive activity. The significance of the presence of… read more here.
Keywords: growth; plant growth; suppressive activity; activity ... See more keywords
Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00646
Abstract: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often… read more here.
Keywords: mdsc exosomes; mdsc suppressive; exosomes may; mdsc ... See more keywords
Is GPNMB the Achilles' Heel of Mo-MDSC While Marking Their Suppressive Activity?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-2334
Abstract: Glycoprotein nonmetastatic B/DC-Hil/Osteoactivin on myeloid-derived suppressor cells impairs T lymphocytes through the binding of Syndecan-4, delineating a new checkpoint pair to be targeted perhaps in combination with PD-1/PD-L1 blockage. See related article by Kobayashi et… read more here.
Keywords: gpnmb achilles; suppressive activity; heel mdsc; achilles heel ... See more keywords
Abstract A72: IFNAR1 signaling regulates PMN-MDSCs immune suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a72
Abstract: Polymorphnuclear myeloid-derived suppressor cells (PMN-MDSCs) are a subset of MDSCs that are expanded and accumulated in several cancers. The main role of PMN-MDSCs in cancer is the suppression of antitumor immune responses, which leads to… read more here.
Keywords: immune suppressive; pmn mdscs; suppressive activity; cancer ... See more keywords
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s157724
Abstract: Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the… read more here.
Keywords: sirt4; activity cancer; suppressive activity; cancer ... See more keywords
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00192
Abstract: A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the… read more here.
Keywords: drd5 signaling; role; suppressive activity; receptor ... See more keywords