Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-1439
Abstract: GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the… read more here.
Keywords: suppressive effects; antibody; gitr; characterization ... See more keywords
The Negative Impact of Triptolide on the Immune Function of Human Natural Killer Cells
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DOI: 10.3390/ph16030458
Abstract: Triptolide (TP), a bioactive compound extracted the from traditional Chinese medicine Tripterygium wilfordii Hook F (TwHF), has been shown to be effective in treating several autoimmune diseases, and has suppressive effects in several key immune… read more here.
Keywords: suppressive effects; natural killer; killer cells; treatment induced ... See more keywords
The Suppressive Effects of Biochar on Above- and Belowground Plant Pathogens and Pests: A Review
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DOI: 10.3390/plants11223144
Abstract: Soilborne pathogens and pests in agroecosystems are serious problems that limit crop yields. In line with the development of more ecologically sustainable agriculture, the possibility of using biochar to control pests has been increasingly investigated… read more here.
Keywords: insects; suppressive effects; plant pathogens; pathogens pests ... See more keywords
Suppressive Effects of a Truncated IK Protein-Derived Peptide on Two Pro-inflammatory Cytokines, IL-17 and TNF-α.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.2004.04062
Abstract: Inhibitor K562 (IK) protein was first isolated from the culture medium of K562, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK)… read more here.
Keywords: tik protein; suppressive effects; inhibitory effects; inflammatory cytokines ... See more keywords