Intrinsic MicroRNA-10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways.
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DOI: 10.1002/advs.202509953
Abstract: Regulatory T cells (Tregs) are indispensable for maintaining immune homeostasis and suppressing excessive inflammatory responses in the intestine. While much attention has focused on positive regulators of Treg differentiation and function, the mechanisms that constrain… read more here.
Keywords: epithelial repair; function; mir 10a; suppressive function ... See more keywords
miR-106a deficiency attenuates inflammation in murine IBD models.
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DOI: 10.1038/s41385-018-0091-7
Abstract: Pro-inflammatory cytokine TNFα antagonizes regulatory T cell (Treg) suppressive function with a measurable reduction of IL-10 protein secretion. Tregs are critical to suppress excessive immune activation, particularly within the intestine where high antigenic loads elicit… read more here.
Keywords: murine; ibd; suppressive function; deficiency ... See more keywords
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production
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DOI: 10.1038/s41598-017-14965-x
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) are indispensable negative regulators of immune responses. To understand Treg biology in health and disease, it is critical to elucidate factors that affect Treg homeostasis and suppressive function. Tregs express… read more here.
Keywords: inducing kinase; regulatory cells; expression; suppressive function ... See more keywords
Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3+ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation
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DOI: 10.3389/fimmu.2022.900139
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and inflammation. There are naturally-derived in the thymus (tTreg), generated extrathymically in the periphery (pTreg), and induced in vitro culture (iTreg) with different… read more here.
Keywords: itreg; inflammation; suppressive function; foxp3 regulatory ... See more keywords
Accumulation and suppressive function of regulatory T cells in malignant ascites: Reducing their suppressive function using arsenic trioxide in vitro
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DOI: 10.3892/ol.2018.7974
Abstract: Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by… read more here.
Keywords: arsenic trioxide; malignant ascites; regulatory cells; ascites derived ... See more keywords