miR-106a deficiency attenuates inflammation in murine IBD models.
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0091-7
Abstract: Pro-inflammatory cytokine TNFα antagonizes regulatory T cell (Treg) suppressive function with a measurable reduction of IL-10 protein secretion. Tregs are critical to suppress excessive immune activation, particularly within the intestine where high antigenic loads elicit… read more here.
Keywords: murine; ibd; suppressive function; deficiency ... See more keywords
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production
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DOI: 10.1038/s41598-017-14965-x
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) are indispensable negative regulators of immune responses. To understand Treg biology in health and disease, it is critical to elucidate factors that affect Treg homeostasis and suppressive function. Tregs express… read more here.
Keywords: inducing kinase; regulatory cells; expression; suppressive function ... See more keywords
Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3+ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.900139
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and inflammation. There are naturally-derived in the thymus (tTreg), generated extrathymically in the periphery (pTreg), and induced in vitro culture (iTreg) with different… read more here.
Keywords: itreg; inflammation; suppressive function; foxp3 regulatory ... See more keywords
Accumulation and suppressive function of regulatory T cells in malignant ascites: Reducing their suppressive function using arsenic trioxide in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.7974
Abstract: Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by… read more here.
Keywords: arsenic trioxide; malignant ascites; regulatory cells; ascites derived ... See more keywords