High-throughput synthetic rescue for exhaustive characterization of suppressor mutations in human genes
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03519-6
Abstract: Inherited or acquired mutations can lead to pathological outcomes. However, in a process defined as synthetic rescue, phenotypic outcome created by primary mutation is alleviated by suppressor mutations. An exhaustive characterization of these mutations in… read more here.
Keywords: exhaustive characterization; synthetic rescue; suppressor; suppressor mutations ... See more keywords
Unique fertility restoration suppressor genes for male-sterile CMS ANN2 and CMS ANN3 cytoplasms in sunflower (Helianthus annuus L.)
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Breeding"
DOI: 10.1007/s11032-018-0922-y
Abstract: Single dominant fertility restoration (Rf) genes for cytoplasmic male-sterile (CMS) sunflower lines CMS ANN2 and CMS ANN3 were previously identified in three and five sources, respectively. However, expressions of the dominant Rf genes were suppressed when… read more here.
Keywords: cms; restoration; suppressor; ann2 cms ... See more keywords
Acoustic attenuation performance prediction and analysis of bladder style hydraulic noise suppressors
Sign Up to like & getrecommendations! Published in 2018 at "Applied Acoustics"
DOI: 10.1016/j.apacoust.2018.01.005
Abstract: Abstract Based on the acoustic-structure coupling and plane wave theory, this paper proposes a method for predicting the acoustic attenuation performance (AAP) of in-line bladder style hydraulic noise suppressor (bladder suppressor) and investigates the influences… read more here.
Keywords: attenuation performance; bladder; suppressor; acoustic attenuation ... See more keywords
Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.064
Abstract: Suppressor of cancer cell invasion (SCAI) is a suppressor of myocardin-related transcription factor (MRTF)-mediated transcription and cancer cell invasion. However, roles of SCAI in the brain and neuronal cells are not fully resolved. In this… read more here.
Keywords: scai; scai variants; suppressor; cell invasion ... See more keywords
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.10.013
Abstract: CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling… read more here.
Keywords: induced treg; gut inflammation; ccr6; ccr6 signaling ... See more keywords
Identification of Strawberry vein banding virus encoded P6 as an RNA silencing suppressor.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.05.003
Abstract: RNA silencing is a common mechanism that plays a key role in antiviral defense. To overcome host defense responses, plant viruses encode silencing-suppressor proteins to target one or several key steps in the silencing machinery.… read more here.
Keywords: protein; rna silencing; silencing suppressor; suppressor ... See more keywords
Natural and Synthetic Suppressor Mutations Defy Stability–Activity Tradeoffs
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00805
Abstract: Thermodynamic stability represents one important constraint on protein evolution, but the molecular basis for how mutations that change stability impact fitness remains unclear. Here, we demonstrate that a prevalent global suppressor mutation in TEM β-lactamase,… read more here.
Keywords: suppressor; natural synthetic; stability; stability activity ... See more keywords
Scan-Find-Scan-Model: Discrete Site-Targeted Suppressor Design Strategy for Amyloid-β.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00272
Abstract: Alzheimer's disease is undoubtedly the most well-studied neurodegenerative disease. Consequently, the amyloid-β (Aβ) protein ranks at the top in terms of getting attention from the scientific community for structural property-based characterization. Even after decades of… read more here.
Keywords: suppressor; site; target sequence; scan find ... See more keywords
The true role that suppressor effects play in condition-based regression analysis: None. A reply to Fiedler (2021).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of personality and social psychology"
DOI: 10.1037/pspp0000428
Abstract: Condition-based regression analysis (CRA) is a statistical method for testing self-enhancement effects. That is, CRA indicates whether, in a set of empirical data, people with higher values on the directed discrepancy self-view S minus reality… read more here.
Keywords: regression analysis; fiedler 2021; condition based; suppressor ... See more keywords
Cucumber RDR1s and cucumber mosaic virus suppressor protein 2b association directs host defence in cucumber plants
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13112
Abstract: Abstract RNA‐dependent RNA polymerases (RDRs) regulate important aspects of plant development and resistance to pathogens. The role of RDRs in virus resistance has been demonstrated using siRNA signal amplification and through the methylation of viral… read more here.
Keywords: cucumber; cmv; mosaic virus; suppressor ... See more keywords
Properties of the feline tumour suppressor reduced expression in immortalized cells (REIC/Dkk-3).
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12254
Abstract: Reduced expression in immortalized cells (REIC/Dkk-3), a member of the human Dickkopf (Dkk) family, is a growth suppressor in human and canine mammary tumours. Mammary gland tumours are common neoplasms with high malignancy in female… read more here.
Keywords: expression; feline mammary; reic dkk; suppressor ... See more keywords