Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation
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DOI: 10.1038/s41598-020-74080-2
Abstract: The tumor suppressor adenomatous polyposis coli (APC) is frequently mutated in colorectal cancers. APC and Axin are core components of a destruction complex that scaffolds GSK3β and CK1 to earmark β-catenin for proteosomal degradation. Disruption… read more here.
Keywords: degradation; tumor suppressor; catenin; catenin degradation ... See more keywords