Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
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DOI: 10.1002/cam4.5387
Abstract: DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a… read more here.
Keywords: function; dna; myeloid derived; suppressor cells ... See more keywords
Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis
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DOI: 10.1002/eji.201646658
Abstract: Increased disease susceptibility during early life has been linked to immune immaturity, regulatory T‐cell/TH2 immune biasing and hyporesponsiveness. The contribution of myeloid derived suppressor cells (MDSCs) remains uninvestigated. Here, we assessed peripheral MDSC in HIV‐infected… read more here.
Keywords: suppressor cells; derived suppressor; hiv; hiv exposed ... See more keywords
Human monocytic myeloid‐derived suppressor cells impair B‐cell phenotype and function in vitro
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DOI: 10.1002/eji.201948240
Abstract: Myeloid‐derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T‐cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited… read more here.
Keywords: suppressor cells; derived suppressor; human monocytic; function ... See more keywords
Targeted deletion of HIF-1α in myeloid cells of neonatal mice: decreased accumulation of myeloid-derived suppressor cells and altered microbiome.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250144
Abstract: The newborn's immune system is faced with the challenge of having to learn quickly to fight off infectious agents, but tolerating the colonization of the body surfaces with commensals without reacting with an excessive inflammatory… read more here.
Keywords: myeloid derived; suppressor cells; hif; myeloid ... See more keywords
Differential gene expression profile in monocytic myeloid‐derived suppressor cells at maternal–fetal interface in a mouse model of spontaneous abortion
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DOI: 10.1002/jcp.27902
Abstract: Monocytic myeloid‐derived suppressor cells (MO‐MDSCs) play an important role in maintaining normal pregnancy. However, it is still not clear what kind of changes in MO‐MDSCs may lead to miscarriage, and which gene expression changes take… read more here.
Keywords: suppressor cells; derived suppressor; monocytic myeloid; gene expression ... See more keywords
c‐Rel‐dependent monocytes are potent immune suppressor cells in cancer
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DOI: 10.1002/jlb.1ma0422-518rr
Abstract: Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of leukocytes that are important for tumorigenesis and tumor immunotherapy. They comprise up to 10% of leukocytes in the blood of tumor patients and their depletion may… read more here.
Keywords: dependent monocytes; tumor; rel dependent; suppressor cells ... See more keywords
Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model
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DOI: 10.1007/s00262-017-2088-6
Abstract: Regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC) are the two important and interactive immunosuppressive components of the tumor microenvironment that hamper anti-tumor immune responses. Therefore, targeting these two populations together might be beneficial… read more here.
Keywords: suppressor cells; derived suppressor; regulatory cells; vaccine ... See more keywords
Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment
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DOI: 10.1007/s00262-019-02388-8
Abstract: Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and… read more here.
Keywords: hmgb1; suppressor cells; derived suppressor; tumor microenvironment ... See more keywords
The effect of l-arginine supplementation and surgical trauma on the frequency of myeloid-derived suppressor cells and T lymphocytes in tumour and blood of colorectal cancer patients.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2021.12.005
Abstract: PURPOSE l-arginine (L-arg) deficiency causes immunosuppression, but it is unknown if L-arg supplementation in colorectal cancer (CRC) patients restores immune system activity. Our objective was to investigate the effect of L-arg supplementation on the frequency… read more here.
Keywords: supplementation; suppressor cells; frequency; test ... See more keywords
Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway.
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DOI: 10.1016/j.canlet.2018.11.002
Abstract: Multiple Myeloma (MM) is an incurable malignancy of terminally differentiated plasma cells, which are predominantly localized in the bone marrow. Myeloid-derived suppressor cells (MDSC) are described to promote MM progression by immunosuppression and induction of… read more here.
Keywords: suppressor cells; derived suppressor; myeloma; multiple myeloma ... See more keywords
Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.02.012
Abstract: Metastatic melanoma is the most dangerous form of skin cancer, with an ever-increasing incidence worldwide. Despite encouraging results with immunotherapeutic approaches, long-term survival is still poor. This is likely partly due to tumour-induced immune suppression… read more here.
Keywords: suppressor cells; derived suppressor; melanoma cells; induction ... See more keywords