Hepatitis B virus X protein impairs α‐interferon signaling via up‐regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24643
Abstract: Hepatitis B Virus (HBV) causes liver cirrhosis and hepatocellular carcinoma. Standard therapy includes treatment with interferon (IFN); however, its efficacy is limited. HBV has been reported to impair IFN signaling; however, the mechanism is unclear.… read more here.
Keywords: protein; cytokine signaling; pp2a; hepatitis virus ... See more keywords
The Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID-19 disease progression.
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in medical virology"
DOI: 10.1002/rmv.2300
Abstract: The family of Suppressor of Cytokine Signalling (SOCS) proteins plays pivotal roles in cytokine and immune regulation. Despite their key roles, little attention has been given to the SOCS family as compared to other feedback… read more here.
Keywords: cytokine signalling; family; socs protein; virus ... See more keywords
Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109615
Abstract: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) engagement with the receptor Fn14 contributes to the fibrotic process of kidney cells in systemic lupus erythematosus. Downregulation of the protein suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: tweak; suppressor cytokine; kidney cells; tweak fn14 ... See more keywords
Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.05.018
Abstract: OBJECTIVE To investigate the impact of deleting Suppressor of Cytokine Signaling (SOCS)-3 (SOCS3) in chondrocytes during murine skeletal development. METHOD Mice with a conditional Socs3 allele (Socs3fl/fl) were crossed with a transgenic mouse expressing Cre… read more here.
Keywords: socs3; deleting suppressor; cytokine signaling; mice ... See more keywords
P1.14-22 The Prognostic Role of the Suppressor of Cytokine Signaling-5 (SOCS5) in Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.08.924
Abstract: Background: Expression of cytokines and growth factors have been shown to be highly correlated with the prognosis in esophageal squamous cell carcinoma (ESCC), a dead disease with poor prognosis. The suppressor of cytokine signaling (SOCS)… read more here.
Keywords: prognosis; cell carcinoma; squamous cell; socs5 ... See more keywords
Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate.
Sign Up to like & getrecommendations! Published in 2019 at "Transplant immunology"
DOI: 10.1016/j.trim.2019.101228
Abstract: Suppressor of cytokine signaling (SOCS) proteins have acknowledged roles in regulation of immune responses. Moreover, their role in the evolution of allograft rejection is being elucidated. In the current investigation, we measured transcript levels of… read more here.
Keywords: cytokine signaling; group; transplant; non rejected ... See more keywords
Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Blood Cancer Journal"
DOI: 10.1038/bcj.2017.67
Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis… read more here.
Keywords: cytokine signaling; expression; myeloid; leukemia ... See more keywords
miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2017577
Abstract: ABSTRACT Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and is associated with high morbidity and mortality. We aimed to study the effects of microRNA-3648 (miR-3648) on LUAD by inhibiting its… read more here.
Keywords: socs2; suppressor cytokine; mir; mir 3648 ... See more keywords
Inhibition of Candida albicans in vivo and in vitro by antimicrobial peptides chromogranin A-N12 through microRNA-155/suppressor of cytokine signaling 1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2017680
Abstract: ABSTRACT Antimicrobial peptides (AMPs) have proven to inhibit a variety of pathogens. Chromogranin A-N12 (CGA-N12) is a kind of AMP, and it is characterized by stable structure, high anti-Candida activity, and good safety. However, it… read more here.
Keywords: suppressor cytokine; cga; antimicrobial peptides; cga n12 ... See more keywords
Characterization of the roles of suppressor of cytokine signaling-3 in esophageal carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2022.185
Abstract: This study was aimed to analyze the diagnostic, therapeutic and prognostic value of the suppressor of cytokine signaling 3 (SOCS3) in pancancer, especially in esophageal carcinoma (ESCA), and investigate the role of SOCS3 in the… read more here.
Keywords: socs3; cytokine signaling; expression; esca ... See more keywords
Prestroke Statins Improve Prognosis of Atrial Fibrillation-Associated Stroke through Increasing Suppressor of Cytokine Signaling-3 Levels
Sign Up to like & getrecommendations! Published in 2021 at "European Neurology"
DOI: 10.1159/000513767
Abstract: Background: Cerebral infarction associated with atrial fibrillation (AF) has relatively higher mortality and morbidity rates than other types of stroke. Statins are being commonly prescribed to patients with stoke. However, the use of statins in… read more here.
Keywords: atrial fibrillation; prestroke statins; cytokine signaling; major disability ... See more keywords