Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
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DOI: 10.1038/s41467-021-22319-5
Abstract: The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in… read more here.
Keywords: fbw7; tumour suppressor; proteasomal degradation; suppressor fbw7 ... See more keywords