Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1886
Abstract: Purpose Epithelial mesenchymal transformation (EMT) has been proposed to play a role in chronic lung allograft dysfunction (CLAD). Liver kinase B1 (LKB1), a tumor suppressor gene, can regulate EMT. However, its role in CLAD development… read more here.
Keywords: tumor suppressor; role; suppressor gene; lung ... See more keywords
Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121779119
Abstract: Significance Cell surface proteins are essential for many biological processes. However, a comprehensive functional analysis of cell surface proteins involved in tumor growth and/or survival is missing. With a de novo designed cell surface sgRNA… read more here.
Keywords: gene kirrel; tumor suppressor; cell surface; suppressor gene ... See more keywords
Electrochemical Determination of the p53 Tumor Suppressor Gene Using a Gold Nanoparticle-Graphene Nanocomposite Modified Glassy Carbon Electrode
Sign Up to like & getrecommendations! Published in 2017 at "Analytical Letters"
DOI: 10.1080/00032719.2016.1178273
Abstract: ABSTRACT A novel sensitive and simple electrochemical DNA sensor is reported for the determination of p53 tumor suppressor gene. A gold nanoparticle/graphene nanocomposite-modified glassy carbon electrode was prepared and methylene blue was used as the… read more here.
Keywords: p53 tumor; tumor suppressor; suppressor gene; determination ... See more keywords
TUSC3: a novel tumour suppressor gene and its functional implications
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13128
Abstract: The tumour suppressor candidate 3 (TUSC3) gene is located on chromosome region 8p22 and encodes the 34 kD TUSC3 protein, which is a subunit of the oligosaccharyl transferase responsible for the N‐glycosylation of nascent proteins.… read more here.
Keywords: suppressor gene; tusc3; tumour suppressor; tumour ... See more keywords
Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-120121-105450
Abstract: A mosaic state arises when pathogenic variants are acquired in certain cell lineages during postzygotic development, and mosaic individuals may present with a generalized or localized phenotype. Here, we review the current state of knowledge… read more here.
Keywords: tumor suppressor; suppressor gene; mosaicism; transmission risk ... See more keywords
SPINK5 is a Tumor-Suppressor Gene Involved in the Progression of Nonsmall Cell Lung Carcinoma through Negatively Regulating PSIP1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/2209979
Abstract: This study aimed to elucidate how SPINK5 affects the malignant phenotypes of NSCLC and the molecular mechanism. NSCLC and adjacent normal tissues were collected to detect the differential level of SPINK5. The influence of SPINK5… read more here.
Keywords: tumor suppressor; tumor; regulating psip1; negatively regulating ... See more keywords
Growth Factor–Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-0666
Abstract: Colorectal cancer is the third most common cancer and the third leading cause of cancer death in the United States. Growth factor–independent 1 (GFI1) is a zinc finger transcriptional repressor responsible for controlling secretory cell… read more here.
Keywords: suppressor gene; cancer; gfi1; tumor suppressor ... See more keywords
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation
Sign Up to like & getrecommendations! Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201606684
Abstract: Cancer genome sequencing projects have identified hundreds of genetic alterations, often at low frequencies, raising questions as to their functional relevance. One exemplar gene is HUWE1, which has been found to be mutated in numerous… read more here.
Keywords: dna damage; huwe1; suppressor gene; tumour suppressor ... See more keywords
Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0502
Abstract: ARMC5 (Armadillo repeat containing 5) was identified as a new tumor suppressor gene responsible for hereditary adrenocortical tumors and meningiomas. ARMC5 is ubiquitously expressed and encodes a protein which contains a N-terminal Armadillo repeat domain… read more here.
Keywords: tumor suppressor; suppressor gene; armc5 ubiquitination; ubiquitination degradation ... See more keywords
Tumor suppressor gene ARMC5 controls adrenal redox state through NRF1 turnover.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0099
Abstract: ARMC5 is a tumor suppressor gene frequently mutated in primary bilateral macronodular adrenal hyperplasia (PBMAH), an adrenal cause of Cushing's syndrome. The function of ARMC5 is poorly understood, aside the fact that it regulates cell… read more here.
Keywords: suppressor gene; tumor; redox; tumor suppressor ... See more keywords
P53 Suppressor Gene Tissue Microarray-based Protein Expression Analysis in Meningiomas
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12946
Abstract: Abstract Background/Aim: Meningiomas represent the main intracranial primary central nervous system (CNS) tumour in adults worldwide. Oncogenes’ over-activation combined with suppressor genes’ silencing affect negatively the biological behavior of these neoplasms. This study aimed to… read more here.
Keywords: p53 suppressor; expression; suppressor gene; meningiomas ... See more keywords