Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24289
Abstract: The present study aimed to explore the changes in the expressions of six tumor‐related genes in myeloproliferative neoplasms (MPNs). The study population included 130 patients with MPNs (52 with chronic myeloid leukemia (CML), 49 with… read more here.
Keywords: oncogenic tumor; suppressor genes; tumor suppressor; pathology ... See more keywords
Gene Expression Array Analysis to Identify Candidate Tumor Suppressor Genes in Melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_54
Abstract: Melanoma is a complex multifactorial disease; therefore, a combination of various approaches is necessary to girt all aspects of its biology and identify the many different genes and factors involved in its etiology.Epigenetic regulation of… read more here.
Keywords: array; tumor suppressor; analysis; expression ... See more keywords
Disease association of human tumor suppressor genes
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-019-01557-9
Abstract: The multifactorial disease, cancer, frequently emerges due to perturbations in tumor suppressor genes (TSGs). However, a growing number of noncanonical target genes of TSGs and the highly interconnected nature of the human interactome reveal that… read more here.
Keywords: tumor suppressor; disease; disease association; cancer ... See more keywords
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma
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DOI: 10.1038/s41417-018-0057-7
Abstract: Understanding the molecular mechanisms for the development of non-Hodgkin lymphoma (NHL) will improve our ability to cure the patients. qRT-PCR was applied for the examination of the efficiency of shRNA for DNMT1, the expression of… read more here.
Keywords: lymphoma; socs3 shp; mir 152; expression ... See more keywords
Correlations between histological characterizations and methylation statuses of tumour suppressor genes in Wilms' tumours
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DOI: 10.1111/iep.12442
Abstract: Wilms' tumour is a solid tumour that frequently occurs in children. Genetic changes in WT1 and epigenetic aberrations that affect imprinted control region 1 in WT2 loci are implicated in its aetiology. Moreover, tumour suppressor… read more here.
Keywords: methylation; suppressor genes; wilms tumours; methylation statuses ... See more keywords
Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao6321
Abstract: Circular ssDNA can sequester inhibitory microRNAs to restore tumor suppressor gene function, thereby inhibiting tumor progression. Protecting tumor suppressors Strategies to target inactive tumor suppressor genes in cancer lag behind advances in targeting oncogenes. In… read more here.
Keywords: tumor suppressor; circular ssdna; silenced tumor; suppressor genes ... See more keywords
Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer
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DOI: 10.1155/2017/2769140
Abstract: Most tumor suppressor genes are commonly inactivated in the development of colorectal cancer (CRC). The activation of tumor suppressor genes may be beneficial to suppress the development and metastasis of CRC. This study analyzed genes… read more here.
Keywords: tumor suppressor; expression; suppressor; crc ... See more keywords
Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3458
Abstract: Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit mechanism and are therefore subject to negative selection. Accordingly, nearly… read more here.
Keywords: suppressor genes; single hit; tumor suppressor; hit inactivation ... See more keywords
Abstract 4078: Sleeping Beauty transposon mutagenesis identifies genes involved in colorectal cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4078
Abstract: Cancer genome sequencing studies have identified numerous genes mutated in colorectal cancers (CRC). Majority of genes, however, were infrequently mutated between tumors. Sorting out infrequent driver genes from passenger genes is still challenging, but important… read more here.
Keywords: tumor suppressor; candidate; cancer; suppressor genes ... See more keywords
Abstract 2623: Identification of KRAS suppressor genes: an ORFeome library screening
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2623
Abstract: The RAS family genes encode small GTP-binding cytoplasmic proteins that are important signaling molecules. They regulate cell growth, survival and differentiation by coupling receptor activation to downstream effector pathways. Activating mutations of oncogenic RAS pathway… read more here.
Keywords: orfeome library; identification kras; suppressor genes; kras suppressor ... See more keywords
Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes
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DOI: 10.1182/blood-2018-99-115176
Abstract: Mice that are homozygous for a hypomorphic allele of the DNA replication factor minichromosome maintenance protein 2 (designated Mcm2hypo) on a C57Bl/6 background are born viable and are healthy for the first 2 months of… read more here.
Keywords: tumor suppressor; suppressor genes; pre lbl; mice ... See more keywords